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A narrative review of the therapeutic and remedial prospects of cannabidiol with emphasis on neurological and neuropsychiatric disorders | Journal of Cannabis Research

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  • Abame MA, He Y, Wu S, Xie Z, Zhang J, Gong X, Wu C, Shen J. Chronic administration of synthetic cannabidiol induces antidepressant effects involving modulation of serotonin and noradrenaline levels in the hippocampus. Neurosci Lett. 2021;744:135594.

    Article 
    PubMed 

    Google Scholar
     

  • Abichabki N, Zacharias LV, Moreira NC, Bellissimo-Rodrigues F, Moreira FL, Benzi JR, Ogasawara T, Ferreira JC, Ribeiro CM, Pavan FR. Potential cannabidiol (CBD) repurposing as antibacterial and promising therapy of CBD plus polymyxin B (PB) against PB-resistant gram-negative bacilli. Sci Reports. 2022;12:1–15.


    Google Scholar
     

  • Abichabki, N., Zacharias, L.V., Moreira, N.C., Bellissimo-Rodrigues, F., Moreira, F.L., Benzi, J.R., Ogasawara, T.M., Ferreira, J.C., Pereira, L.R., Braga, G.Ú. Cannabidiol (CBD) repurposing as antibacterial: Promising therapy of CBD plus polymyxin B against superbugs. bioRxiv.2021 https://doi.org/10.1101/2021.04.12.439341.

  • Alvarez FJ, Lafuente H, Carmen Rey-Santano M, Mielgo VE, Gastiasoro E, Rueda M, Pertwee RG, Castillo AI, Romero J, Martinez-Orgado J. Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic-ischemic newborn piglets. Ped Res. 2008;64:653–8.

    Article 

    Google Scholar
     

  • Anil SM, Shalev N, Vinayaka AC, Nadarajan S, Namdar D, Belausov E, Shoval I, Mani KA, Mechrez G, Koltai H. Cannabis compounds exhibit anti-inflammatory activity in vitro in COVID-19-related inflammation in lung epithelial cells and pro-inflammatory activity in macrophages. Sci Reports. 2021;11:1–14.


    Google Scholar
     

  • Aswad M, Hamza H, Pechkovsky A, Zikrach A, Popov T, Zohar Y, Shahar E, Louria-Hayon I. High-CBD extract (CBD-X) downregulates cytokine storm systemically and locally in inflamed lungs. Front Immunol. 2022;13:2252.

    Article 

    Google Scholar
     

  • Atalay S, Jarocka-Karpowicz I, Skrzydlewska E. Antioxidative and anti-inflammatory properties of cannabidiol. Anti. 2019;9:21.


    Google Scholar
     

  • Autry AE, Monteggia LM. Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol Rev. 2012;64:238–58.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Aziz A-I, Nguyen LC, Oumeslakht L, Bensussan A, Ben Mkaddem S. Cannabinoids as immune system modulators: cannabidiol potential therapeutic approaches and limitations. Cannabis and Cannabinoid Research. 2022;8:254.

    PubMed 

    Google Scholar
     

  • Aziz A-I, Nguyen LC, Oumeslakht L, Bensussan A, Ben Mkaddem S. Cannabinoids as immune system modulators: cannabidiol potential therapeutic approaches and limitations. Cannabis Cannabinoid Res. 2022;8(2):254–69. https://doi.org/10.1089/can.2022.0133.

    Article 
    PubMed 

    Google Scholar
     

  • Bartschi JG, Greenwood L-M, Montgomery A, Dortants L, Weston-Green K, Huang X-F, Pai N, Potter J, Schira MM, Croft R. Cannabidiol as a treatment for neurobiological, behavioral, and psychological symptoms in early-stage dementia: a double-blind, placebo-controlled clinical trial protocol. Cannabis Cannabinoid Res. 2023;8:348–59.

    PubMed 

    Google Scholar
     

  • Basavarajappa BS. Critical enzymes involved in endocannabinoid metabolism. Protein Pept Lett. 2007;14:237–46.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bathina S, Das UN. Brain-derived neurotrophic factor and its clinical implications. Arch Med Sci. 2015;11:1164–78.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Berger M, Li E, Amminger GP. Treatment of social anxiety disorder and attenuated psychotic symptoms with cannabidiol. BMJ Case Reports CP. 2020;13:e235307.

    Article 

    Google Scholar
     

  • Bhunia S, Kolishetti N, Arias AY, Vashist A, Nair M. Cannabidiol for neurodegenerative disorders: A comprehensive review. Front Pharmacol. 2022;13:989717.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Biernacki M, Brzóska MM, Markowska A, Gałażyn-Sidorczuk M, Cylwik B, Gęgotek A, Skrzydlewska E. Oxidative stress and its consequences in the blood of rats irradiated with UV: protective effect of cannabidiol. Anti. 2021;10:821.


    Google Scholar
     

  • Bisogno T, Hanuš L, De Petrocellis L, Tchilibon S, Ponde DE, Brandi I, Moriello AS, Davis JB, Mechoulam R, Di Marzo V. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol. 2001;134:845–52.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Blaskovich MA, Kavanagh AM, Elliott AG, Zhang B, Ramu S, Amado M, Lowe GJ, Hinton AO, Pham DMT, Zuegg J. The antimicrobial potential of cannabidiol. Commun Biol. 2021;4:1–18.

    Article 

    Google Scholar
     

  • Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pathological overproduction: the bad side of adenosine. Br J Pharmacol. 2017;174:1945–60.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Britch SC, Babalonis S, Walsh SL. Cannabidiol: pharmacology and therapeutic targets. Psychopharmacology. 2021;238:9–28.

    Article 
    PubMed 

    Google Scholar
     

  • Cabrera CLR, Keir-Rudman S, Horniman N, Clarkson N, Page C. The anti-inflammatory effects of cannabidiol and cannabigerol alone, and in combination. Pulm Pharmacol Ther. 2021;69:102047.

    Article 

    Google Scholar
     

  • Carbonell WS, Murase S-I, Horwitz AF, Mandell JW. Migration of perilesional microglia after focal brain injury and modulation by CC chemokine receptor 5: an in situ time-lapse confocal imaging study. J Neurosci. 2005;25:7040–7.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Carlini E, Leite J, Tannhauser M, Berardi A. Cannabidiol and Cannabis sativa extract protect mice and rats against convulsive agents. J Pharm Pharmacol. 1973;25:664–5.

    Article 
    PubMed 

    Google Scholar
     

  • Carrier EJ, Auchampach JA, Hillard CJ. Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. Proc Natl Acad Sci. 2006;103:7895–900.

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cassol-Jr OJ, Comim CM, Silva BR, Hermani FV, Constantino LS, Felisberto F, Petronilho F, Hallak JEC, De Martinis BS, Zuardi AW. Treatment with cannabidiol reverses oxidative stress parameters, cognitive impairment and mortality in rats submitted to sepsis by cecal ligation and puncture. Brain Res. 2010;1348:128–38.

    Article 

    Google Scholar
     

  • Cenova A, Nestorovska M, Crcarevska MS, Mihailova L, Shalabalija D, Dodov MG. Evaluation of antioxidant properties of herbal mixture and CBD oil for the treatment of chronic wound. Macedonian Pharm Bull. 2022;68:557–8.

    Article 

    Google Scholar
     

  • Chagas MH, Eckeli A, Zuardi AW, Pena-Pereira MA, Sobreira-Neto MA, Sobreira E, Camilo M, Bergamaschi M, Schenck C, Hallak JEC. Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson’s disease patients: a case series. J Clin Phar Ther. 2014;39:564–6.

    Article 

    Google Scholar
     

  • Chayasirisobhon S. Mechanisms of action and Pharmacokinetics of Cannabis. The Permanente Journal. 2020;25:1–3.

    PubMed 

    Google Scholar
     

  • Chen KA, Farrar M, Cardamone M, Gill D, Smith R, Cowell CT, Truong L, Lawson JA. Cannabidiol for treating drug-resistant epilepsy in children: the New South Wales experience. Med J Aust. 2018;209:217–21.

    Article 
    PubMed 

    Google Scholar
     

  • Chesworth R, Cheng D, Staub C, Karl T. Effect of long-term cannabidiol on learning and anxiety in a female Alzheimer’s disease mouse model. Front Pharmacol. 2022;13:931384.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Consroe P, Laguna J, Allender J, Snider S, Stern L, Sandyk R, Kennedy K, Schram K. Controlled clinical trial of cannabidiol in Huntington’s disease. Pharmacol Biochem Behav. 1991;40:701–8.

    Article 
    PubMed 

    Google Scholar
     

  • Crippa JAS, Derenusson GN, Ferrari TB, Wichert-Ana L, Duran FL, Martin-Santos R, Simões MV, Bhattacharyya S, Fusar-Poli P, Atakan Z. Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. J Psychopharm. 2011;25:121–30.

    Article 

    Google Scholar
     

  • Cuñetti L, Manzo L, Peyraube R, Arnaiz J, Curi L, Orihuela S. Chronic pain treatment with cannabidiol in kidney transplant patients in Uruguay. Transplant Proc. 2018;50(2):461–4.

  • da Silva VK, de Freitas BS, Garcia RCL, Monteiro RT, Hallak JE, Zuardi AW, Crippa JAS, Schröder N. Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload. Transl Psychiatry. 2018;8:1–8.

    Article 

    Google Scholar
     

  • Davidson, E., 2022 https://clinicaltrials.gov/ct2/show/NCT03877991. Bioequivalence Assessment of Cannabidiol (CBD) Administrated in Oral Formulations.

  • de Almeida CM, Brito MM, Bosaipo NB, Pimentel AV, Tumas V, Zuardi AW, Crippa JA, Hallak JE, Eckeli AL. Cannabidiol for rapid eye movement sleep behavior disorder. Mov Disord. 2021;36:1711–5.

    Article 
    PubMed 

    Google Scholar
     

  • De Petrocellis L, Ligresti A, Moriello AS, Allarà M, Bisogno T, Petrosino S, Stott CG, Di Marzo V. Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. Br J Pharmacol. 2011;163:1479–94.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Della Rocca G, Paoletti F, Conti MB, Galarini R, Chiaradia E, Sforna M, Dall’Aglio C, Polisca A, Di Salvo A. Pharmacokinetics of cannabidiol following single oral and oral transmucosal administration in dogs. Front Vet Sci. 2022;9:1104152.

    Article 
    PubMed 

    Google Scholar
     

  • Devinsky O, Cross JH, Laux L, Marsh E, Miller I, Nabbout R, Scheffer IE, Thiele EA, Wright S. Trial of cannabidiol for drug-resistant seizures in the Dravet syndrome. New Engl J Med. 2017;376:2011–20.

    Article 
    PubMed 

    Google Scholar
     

  • Devinsky O, Marsh E, Friedman D, Thiele E, Laux L, Sullivan J, Miller I, Flamini R, Wilfong A, Filloux F. Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. Lancet Neurol. 2016;15:270–8.

    Article 
    PubMed 

    Google Scholar
     

  • Devinsky O, Nabbout R, Miller I, Laux L, Zolnowska M, Wright S, Roberts C. Long-term cannabidiol treatment in patients with Dravet syndrome: An open-label extension trial. Epilepsia. 2019;60:294–302.

    Article 
    PubMed 

    Google Scholar
     

  • Devinsky O, Verducci C, Thiele EA, Laux LC, Patel AD, Filloux F, Szaflarski JP, Wilfong A, Clark GD, Park YD. Open-label use of highly purified CBD (Epidiolex®) in patients with CDKL5 deficiency disorder and Aicardi, Dup15q, and Doose syndromes. Epilepsy Behav. 2018;86:131–7.

    Article 
    PubMed 

    Google Scholar
     

  • di Giacomo V, Chiavaroli A, Orlando G, Cataldi A, Rapino M, Di Valerio V, Leone S, Brunetti L, Menghini L, Recinella L. Neuroprotective and neuromodulatory effects induced by cannabidiol and cannabigerol in rat Hypo-E22 cells and isolated hypothalamus. Anti. 2020;9:71.


    Google Scholar
     

  • Ekiner SA, Gęgotek A, Skrzydlewska E. The molecular activity of cannabidiol in the regulation of Nrf2 system interacting with NF-κB pathway under oxidative stress. Redox Biol. 2022;57:102489.

    Article 

    Google Scholar
     

  • ElBatsh MM, Assareh N, Marsden CA, Kendall DA. Anxiogenic-like effects of chronic cannabidiol administration in rats. Psychopharmacology. 2012;221:239–47.

    Article 
    PubMed 

    Google Scholar
     

  • Elms L, Shannon S, Hughes S, Lewis N. Cannabidiol in the treatment of post-traumatic stress disorder: a case series. J Altern Complement Med. 2019;25:392–7.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • ElSohly MA, Slade D. Chemical constituents of marijuana: the complex mixture of natural cannabinoids. Life Sci. 2005;78:539–48.

    Article 
    PubMed 

    Google Scholar
     

  • England T, O’Sullivan S. Protective effects of Cannabidivarin and Cannabigerol on cells of the blood-brain barrier under ischemic conditions. Cannabis Cannabinoid Res. 2021;6:315–26.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Englund A, Morrison PD, Nottage J, Hague D, Kane F, Bonaccorso S, Stone JM, Reichenberg A, Brenneisen R, Holt D. Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment. J Psychopharmacol. 2013;27:19–27.

    Article 
    PubMed 

    Google Scholar
     

  • Fagherazzi EV, Garcia VA, Maurmann N, Bervanger T, Halmenschlager LH, Busato SB, Hallak JE, Zuardi AW, Crippa JA, Schröder N. Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders. Psychopharmacology. 2012;219:1133–40.

    Article 
    PubMed 

    Google Scholar
     

  • Feoktistov I, Biaggioni I. Role of adenosine A2B receptors in inflammation. Adv Pharmacol. 2011;61:115–44.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fernández-Ruiz J, Sagredo O, Pazos MR, García C, Pertwee R, Mechoulam R, Martínez-Orgado J. Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid? Br J Clin Pharmacol. 2013;75:323–33.

    Article 
    PubMed 

    Google Scholar
     

  • Figler RA, Wang G, Srinivasan S, Jung DY, Zhang Z, Pankow JS, Ravid K, Fredholm B, Hedrick CC, Rich SS. Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans. Diabetes. 2011;60:669–79.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fu X, Xu S, Li Z, Chen K, Fan H, Wang Y, Xie Z, Kou L, Zhang S. Enhanced intramuscular bioavailability of Cannabidiol using nanocrystals: formulation, in vitro appraisal, and pharmacokinetics. AAPS PharmSciTech. 2022;23:85.

    Article 
    PubMed 

    Google Scholar
     

  • García-Arencibia M, González S, de Lago E, Ramos JA, Mechoulam R, Fernández-Ruiz J. Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson’s disease: importance of antioxidant and cannabinoid receptor-independent properties. Brain Res. 2007;1134:162–70.

    Article 
    PubMed 

    Google Scholar
     

  • Ghit A, Assal D, Al-Shami AS, Hussein DEE. GABAA receptors: structure, function, pharmacology, and related disorders. J Genet Engine Biotechnol. 2021;19:1–15.


    Google Scholar
     

  • Gildea L, Ayariga JA, Ajayi OS, Xu J, Villafane R, Samuel-Foo M. Cannabis sativa CBD extract shows promising antibacterial activity against Salmonella typhimurium and S. Newington. Molecules. 2022;27:2669.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Giuliano C. Neuroprotective and symptomatic effects of Cannabidiol in an animal model of Parkinson’s disease. Int J Mol Sci. 2021;22:8920.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Giuliano C, Francavilla M, Ongari G, Petese A, Ghezzi C, Rossini N, Blandini F, Cerri S. Neuroprotective and symptomatic effects of cannabidiol in an animal model of Parkinson’s disease. Int J Mol Sci. 2021;22:8920.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gu Z, Singh S, Niyogi RG, Lamont GJ, Wang H, Lamont RJ, Scott DA. Marijuana-derived cannabinoids trigger a CB2/PI3K axis of suppression of the innate response to oral pathogens. Front Immunol. 2019;10:2288.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hammell D, Zhang L, Ma F, Abshire S, McIlwrath S, Stinchcomb A, Westlund K. Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. Eur J Pain. 2016;20:936–48.

    Article 
    PubMed 

    Google Scholar
     

  • Hampson A, Grimaldi M, Axelrod J, Wink D. Cannabidiol and (−) Δ9-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci. 1998;95:8268–73.

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Han X, Song X, Song D, Xie G, Guo H, Wu N, Li J. Comparison between cannabidiol and sertraline for the modulation of post-traumatic stress disorder-like behaviors and fear memory in mice. Psychopharmacology. 2022;239:1605–20.

    Article 
    PubMed 

    Google Scholar
     

  • Hao E, Mukhopadhyay P, Cao Z, Erdélyi K, Holovac E, Liaudet L, Lee W-S, Haskó G, Mechoulam R, Pacher P. Cannabidiol protects against doxorubicin-induced cardiomyopathy by modulating mitochondrial function and biogenesis. Mol Med. 2015;21:38–45.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Harirforoosh S, Asghar W, Jamali F. Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications. J Pharm Pharm Sci. 2013;16:821–47.

    Article 
    PubMed 

    Google Scholar
     

  • Heineman JT, Forster GL, Stephens KL, Cottler PS, Timko MP, DeGeorge BR Jr. A randomized controlled trial of topical cannabidiol for the treatment of thumb basal joint arthritis. J Hand Surg. 2022;47:611–20.

    Article 

    Google Scholar
     

  • Hermush V, Ore L, Stern N, Mizrahi N, Fried M, Krivoshey M, Staghon E, Lederman VE, Bar-Lev Schleider L. Effects of rich cannabidiol oil on behavioral disturbances in patients with dementia: a placebo controlled randomized clinical trial. Front Med. 2022;9:951889.

    Article 

    Google Scholar
     

  • Hilaire G, Voituron N, Menuet C, Ichiyama RM, Subramanian HH, Dutschmann M. The role of serotonin in respiratory function and dysfunction. Respir Physiol Neurobiol. 2010;174:76–88.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hosseini A, McLachlan AJ, Lickliter JD. A phase I trial of the safety, tolerability and pharmacokinetics of cannabidiol administered as single-dose oil solution and single and multiple doses of a sublingual wafer in healthy volunteers. Br J Clin Pharmacol. 2021;87:2070–7.

    Article 
    PubMed 

    Google Scholar
     

  • Hu X, Li J, Fu M, Zhao X, Wang W. The JAK/STAT signaling pathway: from bench to clinic. Signal Transduct Target Ther. 2021;6:402.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hunter D, Oldfield G, Tich N, Messenheimer J, Sebree T. Synthetic transdermal cannabidiol for the treatment of knee pain due to osteoarthritis. OsCar. 2018;26:S26.


    Google Scholar
     

  • Hurd YL, Spriggs S, Alishayev J, Winkel G, Gurgov K, Kudrich C, Oprescu AM, Salsitz E. Cannabidiol for the reduction of cue-induced craving and anxiety in drug-abstinent individuals with heroin use disorder: a double-blind randomized placebo-controlled trial. Am J Psychiatry. 2019;176:911–22.

    Article 
    PubMed 

    Google Scholar
     

  • Jean‐Gilles L, Braitch M, Latif ML, Aram J, Fahey AJ, Edwards LJ, et al. Effects of pro‐inflammatory cytokines on cannabinoid CB 1 and CB 2 receptors in immune cells. Acta Physiologica. 2015;214(1):63–74.

  • Jenny M, Schröcksnadel S, Überall F, Fuchs D. The potential role of cannabinoids in modulating serotonergic signaling by their influence on tryptophan metabolism. Pharmaceuticals. 2010;3(8):2647–60.

  • Jiang R, Yamaori S, Takeda S, Yamamoto I, Watanabe K. Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes. Life Sci. 2011;89:165–70.

    Article 
    PubMed 

    Google Scholar
     

  • Jones PG, Falvello L, Kennard O, Sheldrick G, Mechoulam R. Cannabidiol. Acta Crystallogr Sect b: Struct Crystallogr Cryst Chem. 1977;33:3211–4.

    Article 
    ADS 

    Google Scholar
     

  • Juan CA, Pérez de la Lastra JM, Plou FJ, Pérez-Lebeña E. The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies. Int J Mol Sci. 2021;22:4642.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jung YJ, Tweedie D, Scerba MT, Greig NH. Neuroinflammation as a factor of neurodegenerative disease: thalidomide analogs as treatments. Front Cell Dev Biol. 2019;7:313.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kanova M, Kohout P. Serotonin—Its synthesis and roles in the healthy and the critically ill. Int J Mol Sci. 2021;22:4837.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kaplan JS, Stella N, Catterall WA, Westenbroek RE. Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome. Proc Natl Acad Sci. 2017;114:11229–34.

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Khaksar S, Bigdeli M, Samiee A, Shirazi-Zand Z. Antioxidant and anti-apoptotic effects of cannabidiol in model of ischemic stroke in rats. Brain Res Bull. 2022;180:118–30.

    Article 
    PubMed 

    Google Scholar
     

  • Kim YS, Joh TH. Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson’s disease. Exp Mol Med. 2006;38:333–47.

    Article 
    PubMed 

    Google Scholar
     

  • Kochen S, Villanueva M, Bayarres L, Daza-Restrepo A, Martinez SG, Oddo S. Cannabidiol as an adjuvant treatment in adults with drug-resistant focal epilepsy. Epilepsy Behav. 2023;144:109210.

    Article 
    PubMed 

    Google Scholar
     

  • Kosgodage US, Matewele P, Awamaria B, Kraev I, Warde P, Mastroianni G, Nunn AV, Guy GW, Bell JD, Inal JM. Cannabidiol is a novel modulator of bacterial membrane vesicles. Front Cell Infect Microbiol. 2019;9:324.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kozela E, Juknat A, Kaushansky N, Rimmerman N, Ben-Nun A, Vogel Z. Cannabinoids decrease the Th17 inflammatory autoimmune phenotype. J Neuroimmune Pharmacol. 2013;8:1265–76.

    Article 
    PubMed 

    Google Scholar
     

  • Laprairie R, Bagher A, Kelly M, Denovan-Wright E. Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor. Br J Pharmacol. 2015;172:4790–805.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Laun AS, Shrader SH, Brown KJ, Song Z-H. GPR3, GPR6, and GPR12 as novel molecular targets: their biological functions and interaction with cannabidiol. Acta Pharmacol Sin. 2019;40:300–8.

    Article 
    PubMed 

    Google Scholar
     

  • Lees R, Hines LA, Hindocha C, Baio G, Shaban ND, Stothart G, Mofeez A, Morgan CJ, Curran HV, Freeman TP. Effect of four-week cannabidiol treatment on cognitive function: secondary outcomes from a randomised clinical trial for the treatment of cannabis use disorder. Psychopharmacology. 2023;240:337–46.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Leweke F, Piomelli D, Pahlisch F, Muhl D, Gerth C, Hoyer C, Klosterkötter J, Hellmich M, Koethe D. Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Transl Psychiatry. 2012;2:e94–e94.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lima Giacobbo B, Doorduin J, Klein HC, Dierckx RA, Bromberg E, de Vries EF. Brain-derived neurotrophic factor in brain disorders: focus on neuroinflammation. Mol Neurobiol. 2019;56:3295–312.

    Article 
    PubMed 

    Google Scholar
     

  • Lin C-C, Huang T-L. Brain-derived neurotrophic factor and mental disorders. Biomed J. 2020;43:134–42.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Linares IM, Zuardi AW, Pereira LC, Queiroz RH, Mechoulam R, Guimarães FS, Crippa JA. Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test. Brazilian J Psychiatry. 2018;41:9–14.

    Article 

    Google Scholar
     

  • Linge R, Jiménez-Sánchez L, Campa L, Pilar-Cuéllar F, Vidal R, Pazos A, Adell A, Díaz Á. Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors. Neuropharmacology. 2016;103:16–26.

    Article 
    PubMed 

    Google Scholar
     

  • Liput DJ, Hammell DC, Stinchcomb AL, Nixon K. Transdermal delivery of cannabidiol attenuates binge alcohol-induced neurodegeneration in a rodent model of an alcohol use disorder. Pharmacol Biochem Behav. 2013;111:120–7.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lodzki M, Godin B, Rakou L, Mechoulam R, Gallily R, Touitou E. Cannabidiol—transdermal delivery and anti-inflammatory effect in a murine model. J Control Release. 2003;93:377–87.

    Article 
    PubMed 

    Google Scholar
     

  • Lowin T, Tingting R, Zurmahr J, Classen T, Schneider M, Pongratz G. Cannabidiol (CBD): A killer for inflammatory rheumatoid arthritis synovial fibroblasts. Cell Death Dis. 2020;11:1–11.

    Article 

    Google Scholar
     

  • Lu H-C, Mackie K. An introduction to the endogenous cannabinoid system. Biol Psychiat. 2016;79:516–25.

    Article 
    PubMed 

    Google Scholar
     

  • Lucas CJ, Galettis P, Schneider J. The pharmacokinetics and the pharmacodynamics of cannabinoids. Br J Clin Pharmacol. 2018;84:2477–82.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Machado Bergamaschi M, Helena Costa Queiroz R, Waldo Zuardi A, Crippa AS. Safety and side effects of cannabidiol, a Cannabis sativa constituent. Curr Drug Safety. 2011;6:237–49.

    Article 

    Google Scholar
     

  • Magen I, Avraham Y, Ackerman Z, Vorobiev L, Mechoulam R, Berry EM. Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation. J Hepatol. 2009;51:528–34.

    Article 
    PubMed 

    Google Scholar
     

  • Mammana S, Cavalli E, Gugliandolo A, Silvestro S, Pollastro F, Bramanti P, Mazzon E. Could the combination of two non-psychotropic cannabinoids counteract neuroinflammation? Effectiveness of cannabidiol associated with cannabigerol. Medicina. 2019;55:747.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mariga A, Mitre M, Chao MV. Consequences of brain-derived neurotrophic factor withdrawal in CNS neurons and implications in disease. Neurobiol Dis. 2017;97:73–9.

    Article 
    PubMed 

    Google Scholar
     

  • Martín-Moreno AM, Reigada D, Ramírez BG, Mechoulam R, Innamorato N, Cuadrado A, de Ceballos ML. Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer’s disease. Mol Pharmacol. 2011;79:964–73.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Martin EL, Strickland JC, Schlienz NJ, Munson J, Jackson H, Bonn-Miller MO, Vandrey R. Antidepressant and anxiolytic effects of medicinal cannabis use in an observational trial. Front Psych. 2021;12:1554.


    Google Scholar
     

  • Martínez-Orgado J, Villa M, Del Pozo A. Cannabidiol for the treatment of neonatal hypoxic-ischemic brain injury. Front Pharmacol. 2021;11:584533.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Massi P, Valenti M, Vaccani A, Gasperi V, Perletti G, Marras E, Fezza F, Maccarrone M, Parolaro D. 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. J Neurochem. 2008;104:1091–100.

    Article 
    PubMed 

    Google Scholar
     

  • Matias I, Gonthier M-P, Orlando P, Martiadis V, De Petrocellis L, Cervino C, Petrosino S, Hoareau L, Festy F, Pasquali R. Regulation, function, and dysregulation of endocannabinoids in models of adipose and β-pancreatic cells and in obesity and hyperglycemia. J Clin Endocrinol Metab. 2006;91:3171–80.

    Article 
    PubMed 

    Google Scholar
     

  • McAllister SD, Murase R, Christian RT, Lau D, Zielinski AJ, Allison J, Almanza C, Pakdel A, Lee J, Limbad C. Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis. Breast Cancer Res Treat. 2011;129:37–47.

    Article 
    PubMed 

    Google Scholar
     

  • McGuire P, Robson P, Cubala WJ, Vasile D, Morrison PD, Barron R, Taylor A, Wright S. Cannabidiol (CBD) as an adjunctive therapy in schizophrenia: a multicenter randomized controlled trial. Am J Psychiatry. 2018;175:225–31.

    Article 
    PubMed 

    Google Scholar
     

  • Mechoulam R, Hanuš L. Cannabidiol: an overview of some chemical and pharmacological aspects. Part I: chemical aspects. Chem Phys Lipid. 2002;121:35–43.

    Article 

    Google Scholar
     

  • Meissner, H., Cascella, M., 2022 https://www.ncbi.nlm.nih.gov/books/NBK556048/

  • Misri S, Kaul K, Mishra S, Charan M, Verma AK, Barr MP, Ahirwar DK, Ganju RK. Cannabidiol inhibits tumorigenesis in cisplatin-resistant non-small cell lung cancer via TRPV2. Cancers (basel). 2022;14:1181.

    Article 
    PubMed 

    Google Scholar
     

  • Mohammed N, Ceprian M, Jimenez L, Ruth Pazos M, Martínez-Orgado J. Neuroprotective effects of cannabidiol in hypoxic ischemic insult. The therapeutic window in newborn mice. CNS Neurol Disord-Drug Targets. 2017;16:102–8 (Formerly Current Drug Targets-CNS & Neurological Disorders).

    Article 
    PubMed 

    Google Scholar
     

  • Morgan CJ, Das RK, Joye A, Curran HV, Kamboj SK. Cannabidiol reduces cigarette consumption in tobacco smokers: preliminary findings. Addict Behav. 2013;38:2433–6.

    Article 
    PubMed 

    Google Scholar
     

  • Muhammad F, Liu Y, Wang N, Zhao L, Zhou Y, Yang H, Li H. Neuroprotective effects of cannabidiol on dopaminergic neurodegeneration and α-synuclein accumulation in C. elegans models of Parkinson’s disease. Neurotoxicology. 2022;93:128–39.

    Article 
    PubMed 

    Google Scholar
     

  • Muñoz-Castañeda JR, Montilla P, Padillo FJ, Bujalance I, Muñoz MC, Muntané J, Túnez I. Role of serotonin in cerebral oxidative stress in rats. Acta Neurobiol Exp. 2006;66:1–6.

    Article 

    Google Scholar
     

  • Murillo-Rodríguez E, Millán-Aldaco D, Palomero-Rivero M, Mechoulam R, Drucker-Colín R. Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats. FEBS Lett. 2006;580:4337–45.

    Article 
    PubMed 

    Google Scholar
     

  • Oláh A, Tóth BI, Borbíró I, Sugawara K, Szöllõsi AG, Czifra G, Pál B, Ambrus L, Kloepper J, Camera E. Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes. J Clin Investig. 2014;124:3713–24.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pan H, Mukhopadhyay P, Rajesh M, Patel V, Mukhopadhyay B, Gao B, Haskó G, Pacher P. Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death. J Pharmacol Exp Ther. 2009;328:708–14.

    Article 
    PubMed 

    Google Scholar
     

  • Pandolfo P, Silveirinha V, dos Santos-Rodrigues A, Venance L, Ledent C, Takahashi RN, Cunha RA, Köfalvi A. Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum. Eur J Pharmacol. 2011;655:38–45.

    Article 
    PubMed 

    Google Scholar
     

  • Patra PH, Barker-Haliski M, White HS, Whalley BJ, Glyn S, Sandhu H, Jones N, Bazelot M, Williams CM, McNeish AJ. Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models. Epilepsia. 2019;60:303–14.

    Article 
    PubMed 

    Google Scholar
     

  • Peng J, Fan M, An C, Ni F, Huang W, Luo J. A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD). Basic Clin Pharmacol Toxicol. 2022;130:439–56.

    Article 
    PubMed 

    Google Scholar
     

  • Peres FF, Diana MC, Levin R, Suiama MA, Almeida V, Vendramini AM, Santos CM, Zuardi AW, Hallak JE, Crippa JA. Cannabidiol administered during peri-adolescence prevents behavioral abnormalities in an animal model of schizophrenia. Front Pharmacol. 2018;9:901.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Peyravian N, Deo S, Daunert S, Jimenez JJ. Cannabidiol as a novel therapeutic for immune modulation. ImmunoTargets Ther. 2020a;9:131.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pokorski I, Clement N, Phung N, Weltman M, Fu S, Copeland J. Cannabidiol in the management of in-patient cannabis withdrawal: clinical case series. Future Neurol. 2017;12:133–40.

    Article 

    Google Scholar
     

  • Porcari GS, Fu C, Doll ED, Carter EG, Carson RP. Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy: Practical experiences in a tertiary medical center. Epilepsy Behav. 2018;80:240–6.

    Article 
    PubMed 

    Google Scholar
     

  • Porter B, Marie BS, Milavetz G, Herr K. Cannabidiol (CBD) use by older adults for acute and chronic pain. J Gerontol Nurs. 2021;47:6–15.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Privitera M, Bhathal H, Wong M, Cross JH, Wirrell E, Marsh ED, Mazurkiewicz-Beldzinska M, Villanueva V, Checketts D, Knappertz V. Time to onset of cannabidiol (CBD) treatment effect in Lennox-Gastaut syndrome: Analysis from two randomized controlled trials. Epilepsia. 2021;62:1130–40.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rajesh M, Mukhopadhyay P, Bátkai S, Patel V, Saito K, Matsumoto S, Kashiwaya Y, Horváth B, Mukhopadhyay B, Becker L. Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. J Am Coll Cardiol. 2010;56:2115–25.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ramer R, Merkord J, Rohde H, Hinz B. Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1. Biochem Pharmacol. 2010;79:955–66.

    Article 
    PubMed 

    Google Scholar
     

  • Richard, R., 2020. A Healthy Inflammatory Response Depends on Neuroendocrine Balance. https://sanescohealth.com/blog/inflammatory-response-and-neuroendocrine-balance/#:~:text=Proinflammatory%20cytokines%20such%20as%20interleukin,to%20a%20reduction%20in%20serotonin.

  • Rieder CR. Cannabidiol in Parkinson’s disease. Bra J Psychiatry. 2020;42:126–7.

    Article 

    Google Scholar
     

  • Rizkallah E, Mongeau-Pérusse V, Lamanuzzi L, Stip E, Juteau L-C, Brissette S, Bruneau J, Dubreucq S, Jutras-Aswad D. Cannabidiol effects on cognition in individuals with cocaine use disorder: exploratory results from a randomized controlled trial. Pharmacol Biochem Behav. 2022;216:173376.

    Article 
    PubMed 

    Google Scholar
     

  • Rodríguez de Fonseca F, Del Arco I, Bermudez-Silva FJ, Bilbao A, Cippitelli A, Navarro M. The endocannabinoid system: physiology and pharmacology. Alcohol Alcohol. 2005;40:2–14.

  • Run M, Yuan-hui S, Na X. Antioxidant effect of cannabidiol in mice with liver fibrosis. Chin J Pub Health. 2022;38:181–5.

  • Russo C, Lavorgna M, Nugnes R, Orlo E, Isidori M. Comparative assessment of antimicrobial, antiradical and cytotoxic activities of cannabidiol and its propyl analogue cannabidivarin. Sci Rep. 2021;11:22494.

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Russo EB. Cannabis therapeutics and the future of neurology. Front Integr Neurosci. 2018;12:51.

  • Russo EB, Burnett A, Hall B, Parker KK. Agonistic properties of cannabidiol at 5-HT1a receptors. Neurochem Res. 2005;30:1037–43.

    Article 
    PubMed 

    Google Scholar
     

  • Sacerdote P, Martucci C, Vaccani A, Bariselli F, Panerai A, Colombo A, Parolaro D, Massi P. The nonpsychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro. J Neuroimmunol. 2005;159:97–105.

    Article 
    PubMed 

    Google Scholar
     

  • Sagredo O, Ramos JA, Decio A, Mechoulam R, Fernández-Ruiz J. Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptors. Eur J Neurosci. 2007;26:843–51.

    Article 
    PubMed 

    Google Scholar
     

  • Sales AJ, Fogaça MV, Sartim AG, Pereira VS, Wegener G, Guimarães FS, Joca SR. Cannabidiol induces rapid and sustained antidepressant-like effects through increased BDNF signaling and synaptogenesis in the prefrontal cortex. Mol Neurobiol. 2019;56:1070–81.

    Article 
    PubMed 

    Google Scholar
     

  • Salimi H, Klein RS. Disruption of the Blood-Brain Barrier During Neuroinflammatory and Neuroinfectious Diseases. In: Mitoma H, Manto M, editors. Neuroimmune Diseases. Contemporary Clinical Neuroscience. 2019. p. 195–234.

  • Sauer AV, Hernandez RJ, Fumagalli F, Bianchi V, Poliani PL, Dallatomasina C, Riboni E, Politi LS, Tabucchi A, Carlucci F. Alterations in the brain adenosine metabolism cause behavioral and neurological impairment in ADA-deficient mice and patients. Sci Rep. 2017;7:1–13.

    Article 

    Google Scholar
     

  • Schiavon AP, Soares LM, Bonato JM, Milani H, Guimarães FS, Weffort de Oliveira RM. Protective effects of cannabidiol against hippocampal cell death and cognitive impairment induced by bilateral common carotid artery occlusion in mice. Neurotox Res. 2014;26:307–16.

    Article 
    PubMed 

    Google Scholar
     

  • Seltzer ES, Watters AK, MacKenzie D Jr, Granat LM, Zhang D. Cannabidiol (CBD) as a promising anti-cancer drug. Cancers (basel). 2020;12:3203.

    Article 
    PubMed 

    Google Scholar
     

  • Shannon S, Lewis N, Lee H, Hughes S. Cannabidiol in anxiety and sleep: a large case series. Permanente J. 2019;23:18.

    Article 

    Google Scholar
     

  • Shannon S, Opila-Lehman J. Effectiveness of cannabidiol oil for pediatric anxiety and insomnia as part of posttraumatic stress disorder: a case report. Perm J. 2016;20:16.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shoval G, Shbiro L, Hershkovitz L, Hazut N, Zalsman G, Mechoulam R, Weller A. Prohedonic effect of cannabidiol in a rat model of depression. Neuropsychobiology. 2016;73:123–9.

    Article 
    PubMed 

    Google Scholar
     

  • Soloey-Nilsen H, Nygaard-Odeh K, Kristiansen MG, Brekke OL, Mollnes TE, Reitan SK, Oiesvold T. Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients. BMC Psychiatry. 2022;22:1–7.

    Article 

    Google Scholar
     

  • Stahl V, Vasudevan K. Comparison of efficacy of cannabinoids versus commercial oral care products in reducing bacterial content from dental plaque: a preliminary observation. Cureus. 2020;12:e6809.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Stence N, Waite M, Dailey ME. Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices. Glia. 2001;33:256–66.

    Article 
    PubMed 

    Google Scholar
     

  • Straiker A, Dvorakova M, Zimmowitch A, Mackie K. Cannabidiol inhibits endocannabinoid signaling in autaptic hippocampal neurons. Mol Pharmacol. 2018;94:743–8.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Szaflarski JP, Bebin EM, Comi AM, Patel AD, Joshi C, Checketts D, Beal JC, Laux LC, De Boer LM, Wong MH. Long-term safety and treatment effects of cannabidiol in children and adults with treatment-resistant epilepsies: expanded access program results. Epilepsia. 2018;59:1540–8.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Thomas A, Baillie G, Phillips A, Razdan R, Ross RA, Pertwee R. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br J Pharmacol. 2007;150:613–23.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Vallée A, Lecarpentier Y, Guillevin R, Vallée J-N. Effects of cannabidiol interactions with Wnt/β-catenin pathway and PPARγ on oxidative stress and neuroinflammation in Alzheimer’s disease. AcBBS. 2017;49:853–66.


    Google Scholar
     

  • Valvassori SS, Elias G, de Souza B, Petronilho F, Dal-Pizzol F, Kapczinski F, Trzesniak C, Tumas V, Dursun S, Nisihara Chagas MH. Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania. J Psychopharm. 2011;25:274–80.

    Article 

    Google Scholar
     

  • van Bergen E, Monnikhof M, Lafeber F, Schutgens R, Mastbergen S, van Vulpen L. The fear for adverse bleeding and cardiovascular events in hemophilia patients using (non-) selective non-steroidal anti-inflammatory drugs: a systematic review reporting on safety. Blood Rev. 2022;56:100987.

    Article 
    PubMed 

    Google Scholar
     

  • Vaseghi S, Arjmandi-Rad S, Eskandari M, Ebrahimnejad M, Kholghi G, Zarrindast M-R. Modulating role of serotonergic signaling in sleep and memory. Pharmacol Rep. 2022;74:1–26.

    Article 
    PubMed 

    Google Scholar
     

  • Victor TR, Hage Z, Tsirka SE. Prophylactic administration of cannabidiol reduces microglial inflammatory response to kainate-induced seizures and neurogenesis. Neuroscience. 2022;500:1–11.

    Article 
    PubMed 

    Google Scholar
     

  • Wade DT, Robson P, House H, Makela P, Aram J. A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms. Clin Rehabil. 2003;17:21–9.

    Article 
    PubMed 

    Google Scholar
     

  • Welty TE, Luebke A, Gidal BE. Cannabidiol: promise and pitfalls: Cannabidiol: promise and pitfalls. Epilepsy Curr. 2014;14:250–2.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wheless JW, Dlugos D, Miller I, Oh DA, Parikh N, Phillips S, Renfroe JB, Roberts CM, Saeed I, Sparagana SP. Pharmacokinetics and tolerability of multiple doses of pharmaceutical-grade synthetic cannabidiol in pediatric patients with treatment-resistant epilepsy. CNS Drugs. 2019;33:593–604.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • White CM. A review of human studies assessing cannabidiol’s (CBD) therapeutic actions and potential. J Clin Pharm. 2019;59:923–34.

    Article 

    Google Scholar
     

  • Winstone, J., Shafique, H., Clemmer, M.E., Mackie, K., Wager-Miller, J. Effects of Tetrahydrocannabinol and Cannabidiol on Brain-Derived Neurotrophic Factor and Tropomyosin Receptor Kinase B Expression in the Adolescent Hippocampus. Cannabis and Cannabinoid Research. 2022 https://doi.org/10.1089/can.2021.0025

  • Wójcik P, Gęgotek A, Žarković N, Skrzydlewska E. Disease-dependent antiapoptotic effects of cannabidiol for keratinocytes observed upon UV irradiation. Int J Mol Sci. 2021;22:9956.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zanelati T, Biojone C, Moreira F, Guimarães FS, Joca SRL. Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors. Br J Pharmacol. 2010;159:122–8.

    Article 
    PubMed 

    Google Scholar
     

  • Zhang Y, Dai Y, Wen J, Zhang W, Grenz A, Sun H, Tao L, Lu G, Alexander DC, Milburn MV. Detrimental effects of adenosine signaling in sickle cell disease. Nat Med. 2011;17:79–86.

    Article 
    PubMed 

    Google Scholar
     

  • Zhang Y, Xia Y. Adenosine signaling in normal and sickle erythrocytes and beyond. Microb Infect. 2012;14:863–73.

    Article 

    Google Scholar
     

  • Zhao J, Gao X, Zhao L, Wang Y, Zhang J, Liu S. Effects of Cannabidiol on Parkinson’s disease in a transgenic mouse model by gut-brain metabolic analysis. Evid-Based Complement Altern Med. 2022;2022:1525113.


    Google Scholar
     

  • Zieba J, Sinclair D, Sebree T, Bonn-Miller M, Gutterman D, Siegel S, Karl T. Cannabidiol (CBD) reduces anxiety-related behavior in mice via an FMRP-independent mechanism. Pharmacol Biochem Behav. 2019;181:93–100.

    Article 
    PubMed 

    Google Scholar
     

  • Zimmerman JJ, von Saint André-von Arnim A, McLaughlin J. Cellular respiration. Ped Crit Care. 2011;4:1058–72.

  • Zuardi AW, Cosme R, Graeff FG, Guimarães F. Effects of ipsapirone and cannabidiol on human experimental anxiety. J Psychopharm. 1993;7:82–8.

    Article 

    Google Scholar
     



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