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Chemical profiling and clustering of various dried cannabis flowers revealed by volatilomics and chemometric processing | Journal of Cannabis Research

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  • Addo PW, Brousseau VD, Morello V, MacPherson S, Paris M, Lefsrud M. Cannabis chemistry, post-harvest processing methods and secondary metabolite profiling: a review. Ind Crops Prod. 2021;170:113743.

    Article 
    CAS 

    Google Scholar
     

  • Atapattu SN, Johnson KRD. 2020. Pesticide analysis in cannabis products. Journal of Chromatography A. 2020;1612:460656.

  • Bahi A, Al Mansouri S, Al Memari E, Al Ameri M, Nurulain SM, Ojha S. β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice. Physiol Behav. 2014;135:119–24.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Bianchi F, Careri M, Mangia A, Musci M. 2007. Retention indices in the analysis of food aroma volatile compounds in temperature-programmed gas chromatography: Database creation and evaluation of precision and robustness. J Separation Sci. 2007;30: 563 – 72.

  • Bicchi C, Maffei M. The Plant Volatilome: methods of analysis. In: Normanly J, editor. High-throughput phenotyping in plants: methods and protocols. Totowa, NJ: Humana; 2012. pp. 289–310.

    Chapter 

    Google Scholar
     

  • Brown AK, Xia Z, Bulloch P, Idowu I, Francisco O, Stetefeld J, Stout J, Zimmer J, Marvin C, Letcher RJ, Tomy G. Validated quantitative cannabis profiling for Canadian regulatory compliance – cannabinoids, aflatoxins, and terpenes. Anal Chim Acta. 2019;1088:79–88.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Calvi L, Pentimalli D, Panseri S, Giupponi L, Gelmini F, Beretta G, Vitali D, Bruno M, Zilio E, Pavlovic R. Comprehensive quality evaluation of medical Cannabis sativa L. inflorescence and macerated oils based on HS-SPME coupled to GC–MS and LC-HRMS (q-exactive orbitrap®) approach. J Pharm Biomed Anal. 2018;150:208–19.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chong IG, Jun CH. Performance of some variable selection methods when multicollinearity is present. Chemometr Intell Lab Syst. 2005;78:103–12.

    Article 
    CAS 

    Google Scholar
     

  • Chong J, Yamamoto M, Xia J. MetaboAnalystR 2.0: from raw Spectra to Biological insights. Metabolites. 2019;9:57.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cicaloni V, Salvini L, Vitalini S, Garzoli S. Chemical profiling and characterization of different cultivars of Cannabis sativa L. inflorescences by SPME-GC-MS and UPLC-MS. Separations. 2022;9:90.

    Article 
    CAS 

    Google Scholar
     

  • de Vries A, Ripley BD. (2024). _ggdendro: Create Dendrograms and Tree Diagrams Using’ggplot2’_. R package version 0.2.0, https://CRAN.Rproject.org/package=ggdendro.

  • Deng H, He R, Long M, Li Y, Zheng Y, Lin L, Liang D, Zhang X, Liao M, Lv X. Comparison of the fruit volatile profiles of five muscadine grape cultivars (Vitis rotundifolia Michx.) Using HS-SPME-GC/MS combined with multivariate statistical analysis. Front Plant Sci. 2021;12:728891.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Elzinga S, Fischedick J, Podkolinski R, Raber JC. Cannabinoids and terpenes as chemotaxonomic markers in cannabis. Nat Prod Chem Res. 2015;3:1–9.


    Google Scholar
     

  • Feng X, Wang H, Wang Z, Huang P, Kan J. Discrimination and characterization of the volatile organic compounds in eight kinds of huajiao with geographical indication of China using electronic nose, HS-GC-IMS and HS-SPME-GC–MS. Food Chem. 2022;375:131671.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Fernández N, Lanosa DA, Janezic NS, Quiroga PN. Development and validation of a GC-MS method for quantification of terpenes in cannabis oil (Cannabis sativa L.). Application to commercially available preparations in Argentina. J Appl Res Med Aromatic Plants. 2023;35:100466.


    Google Scholar
     

  • Fischedick JT. Identification of Terpenoid Chemotypes among High (–)-trans-∆9- tetrahydrocannabinol-producing Cannabis sativa L. Cultivars. Cannabis Cannabinoid Res. 2017;2:34–47.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Franchina FA, Dubois LM, Focant JF. In-Depth Cannabis Multiclass Metabolite Profiling using Sorptive extraction and Multidimensional Gas Chromatography with low- and high-resolution Mass Spectrometry. Anal Chem. 2020;92:10512–20.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gilbert AN, DiVerdi JA. Consumer perceptions of strain differences in Cannabis aroma. PLoS ONE. 2018;13:e0192247.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Girard B. Retention index calculation using Kováts constant model for linear temperature-programmed gas chromatography. J Chromatogr A. 1996;721:279–88.

    Article 
    CAS 

    Google Scholar
     

  • Gulluni N, Re T, Loiacono I, Lanzo G, Gori L, Macchi C, Epifani F, Bragazzi N, Firenzuoli F. Cannabis essential oil: a preliminary study for the evaluation of the brain effects. Evidence-Based Complement Altern Med. 2018;2018:1–11.

    Article 

    Google Scholar
     

  • Hanuš LO, Hod Y. Terpenes/terpenoids in cannabis: are they important? Med Cannabis Cannabinoids. 2020;3:25–60.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hazekamp A, Tejkalová K, Papadimitriou S, Cannabis. From Cultivar to Chemovar II—A Metabolomics Approach to Cannabis classification. Cannabis Cannabinoid Res. 2016;1:202–15.

    Article 
    CAS 

    Google Scholar
     

  • Humston-Fulmer EM, Alonso DE, Binkley JE. Chapter six – improving cannabis differentiation by expanding coverage of the chemical profile with GCxGC- TOFMS. Compr Anal Chem. 2020;90:169–96.

    CAS 

    Google Scholar
     

  • Ibrahim EA, Wang M, Radwan MM, Wanas AS, Majumdar CG, Avula B, Wang YH, Khan IA, Chandra S, Lata H. Analysis of terpenes in Cannabis sativa L. using GC/MS: method development, validation, and application. Planta Med. 2019;85:431–8.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Janta P, Pinyo D, Yodta Y, Vasasiri P, Weidenbach M, Pursch M, Yang XG, Kulsing C. A multi- location peak parking approach for calculation of second dimensional retention indices for improved volatile compound identification with cryogen-free comprehensive heart- cut two-dimensional gas chromatography. Anal Methods. 2021a;13:124–32.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Janta P, Pinyo D, Yodta Y, Vasasiri P, Weidenbach M, Pursch M, Yang XG, Kulsing C. Strategies towards simpler configuration and higher peak capacity with comprehensive multidimensional gas chromatography. RSC Adv. 2021b;11:7946–53.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jin D, Henry P, Shan J, Chen J. Identification of chemotypic markers in three chemotype categories of Cannabis using secondary metabolites profiled in inflorescences, leaves, stem bark, and roots. Front Plant Sci. 2021;12:699530.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kakanopas P, Janta P, Vimolmangkang S, Hermatasia F, Kulsing C. Retention index based approach for simulation of results and application for validation of compound identification in comprehensive two-dimensional gas chromatography. J Chromatogr A. 2022;1679:463394.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kamal BS, Kamal F, Lantela DE. Cannabis and the anxiety of fragmentation—a systems approach for finding an anxiolytic cannabis chemotype. Front NeuroSci. 2018;12:730.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kasote D, Lee J, Sreenivasulu N. Volatilomics in plant and agricultural research: recent trends. Front Plant Sci. 2023;14:1289998.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kwaśnica A, Pachura N, Carbonell-Barrachina ÁA, Issa-Issa H, Szumny D, Figiel A, Masztalerz K, Klemens M, Szumny A. Effect of drying methods on chemical and sensory properties of Cannabis sativa leaves. Molecules. 2023;28:8089.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Langa S, Magwaza LS, Mditshwa A, Tesfay SZ. Characterization of cannabis varieties and the intrinsic and extrinsic factors affecting cannabis germination and seedling establishment: a descriptive review. Ind Crops Prod. 2024;208:117861.

    Article 
    CAS 

    Google Scholar
     

  • Lê JJ, Husson F. FactoMineR: an R package for multivariate analysis. J Stat Softw. 2008;25:1–18.

    Article 

    Google Scholar
     

  • Ma QL, Hamid N, Bekhit AED, Robertson J, Law TF. Optimization of headspace solid phase microextraction (HS-SPME) for gas chromatography mass spectrometry (GC–MS) analysis of aroma compounds in cooked beef using response surface methodology. Microchem J. 2013;111:16–24.

    Article 
    CAS 

    Google Scholar
     

  • Maayah ZH, Takahara S, Ferdaoussi M, Dyck JR. The molecular mechanisms that underpin the biological benefits of full-spectrum cannabis extract in the treatment of neuropathic pain and inflammation. Biochim Et Biophys Acta (BBA)-Molecular Basis Disease. 2020;1866:165771.

    Article 
    CAS 

    Google Scholar
     

  • Mahattanatawee K, Rouseff R, Valim MF, Naim M. Identification and aroma impact of norisoprenoids in Orange Juice. J Agric Food Chem. 2005;53:393–7.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Meschler JP, Howlett AC. Thujone exhibits low affinity for cannabinoid receptors but fails to evoke cannabimimetic responses. Pharmacol Biochem Behav. 1999;62:473–80.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Micalizzi G, Vento F, Alibrando F, Donnarumma D, Dugo P, Mondello L, Cannabis Sativa L. A comprehensive review on the analytical methodologies for cannabinoids and terpenes characterization. J Chromatogr A. 2021;1637:461864.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Myers C, Herrington JS, Hamrah P, Anderson K. Accelerated solvent extraction of terpenes in Cannabis coupled with various injection techniques for GC-MS analysis. Front Chem. 2021;9:619770.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pachura N, Zimmer A, Grzywna K, Figiel A, Szumny A, Łyczko J. Chemical investigation on Salvia officinalis L. affected by multiple drying techniques–the comprehensive analytical approach (HS-SPME, GC–MS, LC-MS/MS, GC-O and NMR). Food Chem. 2022;397:133802.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Qamar S, Torres YJM, Parekh HS, Robert Falconer J. Extraction of medicinal cannabinoids through supercritical carbon dioxide technologies: a review. J Chromatogr B. 2021;1167:122581.

    Article 
    CAS 

    Google Scholar
     

  • R Core Team. R: a Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2024.


    Google Scholar
     

  • Radwan MM, Wanas AS, Chandra S, ElSohly MA. Natural cannabinoids of cannabis and methods of analysis. Cannabis sativa L -botany Biotechnol. 2017;161–82.

  • Sommano SR, Chittasupho C, Ruksiriwanich W, Jantrawut P. Cannabis Terpenes Molecules. 2020;2:5792.


    Google Scholar
     

  • Stenerson K, Halpenny MR. Analysis of terpenes in Cannabis using headspace solid-phase microextraction and GC–MS. Spectrosc Supplements. 2017;32:27–32.


    Google Scholar
     

  • Stith SS, Li X, Diviant JP, Brockelman FC, Keeling KS, Hall B, Vigil JM. The effectiveness of inhaled Cannabis flower for the treatment of agitation/irritability, anxiety, and common stress. J Cannabis Res. 2020;2:47.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Thongdorn-Ae N, Nhujak T, Janta P, Rueangthaweep A, Hinchiranan N, Kulsing C. Cryogen-free comprehensive heartcut multidimensional gas chromatography using a Deans switch for improved analysis of petrochemical products derived from palmitic acid oxidation. Anal Methods. 2020;12:5160–7.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Thurman EM. Chapter Seven – Analysis of terpenes in hemp (Cannabis sativa) by gas chromatography/mass spectrometry: Isomer identification analysis. In Comprehensive Analytical Chemistry, Ferrer, I.; Thurman, E. M., Eds. Elsevier: 2020;Vol. 90, pp 197–233.

  • Tungkijanansin N, Vimolmangkang S, Kulsing C, Varanusupakul P. Comprehensive two-dimensional gas chromatography using a miniaturized multiloop splitter-based non-cryogenic artificial trapping (M-SNAT) modulation device for analysis of cannabis samples. J Pharm Biomed Anal. 2024;249:116395.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Vas G, Vekey K. Solid-phase microextraction: a powerful sample preparation tool prior to mass spectrometric analysis. J Mass Spectrom. 2004;39:233–54.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Vigil JM, Stith SS, Brockelman F, Keeling K, Hall B. Systematic combinations of major cannabinoid and terpene contents in Cannabis flower and patient outcomes: a proof-of-concept assessment of the Vigil Index of Cannabis chemovars. J Cannabis Res. 2023;5:4.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wei S, Xiao X, Wei L, Li L, Li G, Liu F, Xie J, Yu J, Zhong Y. Development and comprehensive HS-SPME/GC–MS analysis optimization, comparison, and evaluation of different cabbage cultivars (Brassica oleracea L. var. capitata L.) volatile components. Food Chem. 2021;340:128166.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Weston-Green K, Clunas H, Jimenez Naranjo C. A review of the potential use of pinene and linalool as terpene-based medicines for brain health: discovering novel therapeutics in the flavours and fragrances of cannabis. Front Psychiatry. 2021;12:583211.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yudthavorasit S, Wongravee K, Leepipatpiboon N. Characteristic fingerprint based on gingerol derivative analysis for discrimination of ginger (Zingiber officinale) according to geographical origin using HPLC-DAD combined with chemometrics. Food Chem. 2014;158:101–11.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zheng J, Liang R, Wu C, Zhou R, Liao X. Discrimination of different kinds of Luzhou-flavor raw liquors based on their volatile features. Food Res Int. 2014;56:77–84.

    Article 
    CAS 

    Google Scholar
     

  • Zuur AF, Ieno EN, Meesters EH. A beginner’s guide to R. Volume 150. New York: Springer; 2009.

    Book 

    Google Scholar
     



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